[HTML][HTML] Future options of molecular-targeted therapy in small cell lung cancer

AB Schulze, G Evers, A Kerkhoff, M Mohr… - Cancers, 2019 - mdpi.com
… for paclitaxel and … IB studies evaluated the synergistic use of everolimus for combined
therapies. Sun et al. evaluated n = 21 pretreated SCLC patients using a treatment with everolimus (…

Second-line treatments of small-cell lung cancers

N Baize, I Monnet, L Greillier, G Quere… - Expert Review of …, 2017 - Taylor & Francis
… for relapsed small cell lung cancer (SCLC) patients remain a challenge, with limited clinical
benefit because of rapid tumorEverolimus, an mTOR inhibitor, was evaluated in a phase II …

[HTML][HTML] Phase 1b trial of anti-VEGF/PDGFR vorolanib combined with immune checkpoint inhibitors in patients with advanced solid tumors

NA Bagegni, H Park, K Kraft, M O-Toole, F Gao… - Cancer Chemotherapy …, 2022 - Springer
… We conducted a phase 1b study of vorolanib (300 or 400 mg … squamous cell cancer and 1
small cell lung cancer). Two … of vorolanib plus everolimus combination over everolimus alone …

Nivolumab plus ipilimumab as first-line treatment for advanced non-small-cell lung cancer (CheckMate 012): results of an open-label, phase 1, multicohort study

MD Hellmann, NA Rizvi, JW Goldman… - The lancet …, 2017 - thelancet.com
… “combination” and “lung”. Anti-PD-1 monotherapies have shown improved survival compared
with docetaxel in patients with advanced non-small-cell lung cancer (NSCLC) previously …

[HTML][HTML] Synergies of targeting tumor angiogenesis and immune checkpoints in non-small cell lung cancer and renal cell cancer: from basic concepts to clinical reality

A Pircher, D Wolf, A Heidenreich, W Hilbe… - International Journal of …, 2017 - mdpi.com
… with carboplatin plus paclitaxel in a phase III study with or without … In addition, a phase 1b
study concerning the safety and … of lenvatinib plus everolimus or lenvatinib plus pembrolizumab …

[HTML][HTML] Emerging therapeutic agents for lung cancer

B Dholaria, W Hammond, A Shreders, Y Lou - Journal of Hematology & …, 2016 - Springer
… for small cell lung cancer (SCLC) and non-small-cell lung … , veliparib in combination with
carboplatin and paclitaxel was … ) have been tested in phase 1b study and found to be safe with …

[HTML][HTML] Targeted drugs in small-cell lung cancer

M Santarpia, MG Daffinà, N Karachaliou… - … lung cancer research, 2016 - ncbi.nlm.nih.gov
… received everolimus at three different doses in combination with paclitaxel. At the dose of 5
mg once daily in combination with paclitaxel, everolimus showed an acceptable safety profile …

Novel PI3K/Akt/mTOR pathway inhibitors plus radiotherapy: strategy for non-small cell lung cancer with mutant RAS gene

K Chen, Z Shang, A Dai, P Dai - Life Sciences, 2020 - Elsevier
… 2 study of Papadimitrakopoulou [168] et al. evaluated the tolerability and disease control of
Everolimus and erlotinib in patients … A phase 1b trial about RAD001 combined with standard-…

Lenvatinib plus pembrolizumab in patients with advanced endometrial cancer: an interim analysis of a multicentre, open-label, single-arm, phase 2 trial

V Makker, D Rasco, NJ Vogelzang, MS Brose… - The Lancet …, 2019 - thelancet.com
… endometrial carcinoma, after establishing the maximum tolerated dose in a phase 1b
study. … or paclitaxel in patients with advanced endometrial cancer is recruiting (NCT03517449). …

Lenvantinib: a tyrosine kinase inhibitor of VEGFR 1-3, FGFR 1-4, PDGFRα, KIT and RET

S Zschäbitz, C Grüllich - Small Molecules in Oncology, 2018 - Springer
… non-small cell lung cancer (NSCLC), small cell lung cancer (… of lenvatinib plus everolimus
in n = 20 patients with mRCC. … Another phase 1b study tested the combination of lenvatinib 24 …